Inherited Breast Cancer
نویسندگان
چکیده
During an eight-year period (January 1991– anuary 1999) a total of 11,200 women were xamined at the breast out-patient Department of he University Hospital. Of these, 7,750 were registered for the first time and 3,450 repeated their visit for different reasons. Of the 7,750 women, breast cancer was diagnosed in 261, who were treated appropriately. Out of the 261 breast cancer patients 9 (3.44%) had a family history. We summarise the collected data of these 9 patients in Table 1. The mean age of these 9 patients is 46 years and the median age 49.2 years. Additionally, the mean time of FU is 47 months and the median time 40.77 months. Two procedures are ongoing: the immunohistochemical evaluation of the monoclonal antibody BRCA1 (oncogene) and the molecular study of the BRCA1 and BRCA2 germline mutation.
منابع مشابه
Minor role of BRCA2 mutation (Exon2 and Exon11) in patients with early-onset breast cancer amongst Iranian Azeri-Turkish women
Objective(s): Breast cancer is the most common cancer in women. Every year, one million new cases are reported worldwide, representing 18% of the total number of cancer in women. Hereditary BRCA1 and BRCA2 mutations account for about 60% of inherited breast cancer and are the only known causes of hereditary breast cancer syndrome. The aim of this study was to determine the frequency of BRCA2 (e...
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Introduction: Breast cancer is the most common malignancy in women worldwide. BRCA1 is a tumor suppressor gene that is involved in DNA-damage repair. One of the significant risk factors of breast cancer is the family history. BRCA1 gene consists of 24 exons that encode a protein with 1863 amino acids. Exon 11 is the largest exons and most of the disease-linked mutations have been found in it. I...
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